Aspirin can reduce the risk of cancer in people who are overweight

A randomized trial in the uk showed that cancer risk often increases in overweight people can will reverse when regular doses of aspirin daily.

The research was published in the Journal of Clinical Oncology, is funded by the Uk Medical Research Council, cancer research Uk.

Randomized trials have shown that the risk of cancer often increase in overweight people can will reverse when regular doses of aspirin.

Aspirin is a type of non-steroidal anti-inflammatory drug (NSAID) that can be used for pain relief, antipyretic and anti-inflammatory.

The researchers evaluated the effectiveness of drugs in a 10-year-long research on 937 Lynch syndrome-a genetic disorder diseases that increase the risk of cancer, especially cancer of the colon and uterine cancer.

Among these patients, the researchers found that being overweight will double the risk of colon cancer. However, this risk can be reversed with the use of regular doses of aspirin

"This is very important for the people with Lynch syndrome," study author Sir John Burn, Professor of Clinical Genetics at Newcastle University in England said. "A lot of people struggle with cancer risks due to excess weight and this shows that cancer risk can be eliminated by using an aspirin."

In this study, a group of researchers from more than 43 in 16 countries have provided a test to improve the participant's Lynch Syndrome was assigned at random into two groups: half are taking two aspirin (600 mg) per day for 2 years and the other half placebo.

The participants are then monitored for 10 years, at which a total of 55 people developed colon cancer. The researchers discovered that those involved in obesity is likely to develop into cancer folded 2.75 times the participants had normal weight.

However, among the participants drank 2 aspirin each day, the researchers found that the risk of cancer of the colon is the same whether the participants have been obese or not.

Per unit of body mass index (BMI) increased to increase the risk of colon cancer is 7%. John Mathers, Professor of human nutrition at the University of Newcastle, said that surprisingly the obesity is a driver of cancer even in those with a genetic predisposition to this disease.

"Indeed, the risk of obesity related has increased twice the risk for people with Lynch syndrome as well as for the general population," he added.

Because aspirin appears to stop before the earliest stages of the tumor when it develops, the researchers believe that aspirin can affect the ease of cells becoming cancerous.

Quick information about aspirin

Aspirin is often used as a form of mild pain, reducing fever and anti-inflammatory.

Aspirin is also indicated to prevent blood clot formation in patients at high risk of having a heart attack and stroke

Worldwide estimates there are about 40000 tons of aspirin are consumed annually.

"We can see a mechanism in humans, according to which aspirin is recommended genetic damage from stem cells to undergo cell death," Professor Burn shows. " This will have an impact on cancer. "

One possibility is that aspirin inhibits inflammatory response or increase in obesity. There is increasing evidence that when the process of inflammation associated with an increased risk of cancer.

While everyone should try to maintain a balance weight, PROF. Mathers suggests that aspirin may help patients suffering from obesity are difficult to find a way to lose weight.

The researchers believe that the need to conduct further studies to confirm and identify the correct level of protection aspirin for people have a high BMI.

GS Burn also said that anyone before you start taking aspirin regularly, they need to consult a physician, because aspirin can cause some side effects for the stomach, such as inflammation, ulcers. He adds:

"But if there is a family history of high cancer risk, weigh between benefits and costs, especially side effects with the stomach, we can use the aspirin"

The researchers now plan to conduct a larger track trials related to 3000 participants from around the world to examine the influence of different doses of aspirin and reviewed with a lower dose may be sufficient to protect the body.