Bedaquiline, the new TB drugs

According to the World Health Organization (WHO), 1/3 of world population are carrying Bacillus causing tuberculosis. Every year, about 10 million cases of sick and from 2-3 million people dying from this disease, especially in the developing countries.

Currently there are about 300,000 new tuberculosis cases were resistant to this status and are on the increase. According to the World Health Organization (WHO), 1/3 of world population are carrying Bacillus causing tuberculosis. Every year, about 10 million cases of sick and from 2-3 million people dying from this disease, especially in the developing countries.

Advantages of bedaquilin

Bedaquilin (trade name sirturo) is an anti-tuberculosis drug group diarylquinolin, was discovered by a team of scientists led by Koen Andries headed in the pharmaceutical company Janssen Pharmaceutica. This is the first new tuberculosis medicines research, following testing during the past 40 years since the emergence of drug-resistant tuberculosis rifampine was manufactured in 1963. The special thing is that it is proven to have the ability to treat resistant TB-a littering problem currently when tuberculosis tend to increase with the difficult form of treatment and expensive in terms of money.

Bedaquilin has brought many new promising in fighting tuberculosis-a disease kills more people in the world and only behind the AIDS-after satisfactory results from the experiments on mice. An experiment by the pharmaceutical group Johnson and Johnson made with the participation of research groups in Belgium, France and Sweden. Bedaquilin impact of the ATP synthase molecules are proton pump (this is specialized in molecular synthesis of ATP is the energy for the active bacteria), do disable this molecule. This mechanism is not the same with the smoking group quinolon drug's impact on DNA gyrase (a DNA cutting enzyme is). Also had the smoking group quinolon inhibit the process of Division of TB bacilli was used long ago as levofloxacin or ofloxacin. However, the discovery of bedaquillin is regarded as the hope for resistant tuberculosis patients at present.

According to the research group, this drug has the effect of disabling the enzyme allows substances Bacillus tuberculosis arise active energy needed, at the same time go to the destruction of nature of this enzyme. The scientist Hans Koen Andries said, the new drugs in combination with isoniazide and pyrazinamide antibiotic two kinds will focus in the lungs and the body of infection Mycobacterium tuberculosis to destroy them. This is a different operation mechanism with 3 rows of anti-tuberculosis drugs 1 include rifampine, isoniazide and pyrazinamide, are combined in the treatment of tuberculosis so far. After 1 month of treatment with the antibiotic, treatment time in mouse experiments reduced twice in comparison with current treatment methods. In addition, one template experiments showed bacilli have completely disappeared after 2 months of treatment.

Some note when taking medication

Bedaquilin was first introduced in 2004 at the Scientific Conference on antibiotics and chemotherapy (ICAAC), after a research process that lasted 7 years. One of the first clinical study of bedaquillin is a testing phase II with 47 patients, showed that the drug has the effect of reducing the time from detection to be tuberculosis in sputum sputum no longer transplant to tuberculosis bacilli. A phase II trial was next published in 2010, was funded by Tibotec and the TB Alliance organization. The drug is manufactured by Johnson Johnson (J&J) &, corporations have been approved by the FDA for the drug, a form of temporary approval for these diseases lack of other viable treatment options. By achieving a temporary approval for a drug treatment for a forgotten disease such as tuberculosis, now, J&J can urge the FDA to review drugs in the future to take on the pharmaceutical market as a new achievement in the fight against tuberculosis. The FDA has formally approved this drug for the treatment of tuberculosis as part of the program quick approval apply only with multi drug-resistant tuberculosis.

However, at present, there is still some controversy surrounding the approval of the drug as the FDA's decision was based on an alternate results (implanted phlegm) going backwards with the mortality rate. In the clinical trials advocating approval, patients drink bedaquilin have a higher risk of death even though the results showed tuberculosis bacilli phlegm implantation be resolution. The unwanted effects of the most popular bedaquilin in the study include nausea, muscle pain and headache, chest. Smoking also warned the black box (which is a kind of warning on the packaging of the drugs used as single) demonstrates that the study showed the drug significantly influence risk of serious or even life-threatening, causing cardiac arrhythmia and prolonged QT syndrome caused by hERG channel blockers (a potassium-channel role in the electrical activity of the heart).

Antibiotics originating quite a surprise

Have you ever thought of taking the pills themselves drink ingredients are extracted from the insect's brain, the sediment on the sea bottom, the skin of frog or raccoon can't...?

Think of antibiotics, everyone assumed it was transplanted from the category of antibiotic drug pilicilin-type fungus.

But have you ever thought of taking the pills themselves drink ingredients are extracted from the insect's brain, the sediment on the sea bottom, the skin of frogs, pandas ...? Below is a list of the types of antibiotics are the most exotic origins are discovered by scientists in recent years.

Cockroach brains

You can tell that the cockroaches are nasty little creatures, foul but they can help protect you against some of the rare disease. In a study published in 2010, researchers from the University of Nottingham, United Kingdom, reported that they had successfully extracted a antibiotics retrieved components from cockroaches, grasshoppers have brain brain crushed.

This drug has the ability to destroy many types of bacteria including Escherichia coli strains in bacteria (e. coli)-causes of meningitis and bacteria methicillin-resistant Staphylococcus (MRSA) causes infections "staph" do not respond to conventional antibiotic treatment.

TS. Naveed Khan, the lead author of the study and said the discovery of antibiotics against cockroach brains extracted from MRSA is a special step because the disease is resistant to many antibiotics so do not yet have effective treatments. Also according to TS. Khan, the idea to study antibiotics from the insect comes from the question why the cockroach species live in filthy environment, filled with bacteria, parasites can survive healthily.

The crocodile

Scientists wonder why wounds of a crocodile always recovered quickly after the attacks his prey. We have a strong immune system. Scientists see potential value source crocodile for a powerful antibiotics can be used to combat bacterial infections related to diabetic ulcers and severe burns.

In 2008, a study by scientists from McNeese State University and Louisiana State University, United States of America showed that proteins extracted from the leukemia cells can destroy the crocodile a range of health-threatening bacteria including MRSA bacteria. Scientists are trying to implant special protein from crocodiles on the surface of the bacteria and then this protein will quickly penetrate, break the internal structure of the bacteria and kill them.

Mucous catfish

Types of catfish like catfish, catfish, catfish fish three fish, Pangasius, sa living in water under the floor, near the mud frequently exposed to the bacterium causing the disease but that does not seem to harm them. This has led scientists interest and study, they found that the mucous secretions catfish onto the skin of antibodies that help fight disease-causing bacteria. In a study published in the journal of applied science in 2011, Indian scientists have collected the epidermal mucilage from catfish and spotted the mucus from fish skin are very effective in inhibiting the growth of bacteria dangerous to human health as : E. coli, Klebsiella pneumoniae.

Microorganisms from ocean sediments

Though anthrax can be treated with existing antibiotics like ciprofloxacin but there is always the possibility of this disease-causing bacteria become resistant to antibiotics. Therefore, scientists at Scripps Center, Institute for biological and biomedical Marine Research, America and discovered a new compound anthracimycin, initial tests showed it was able to destroy the powerful for both anthrax and MRSA. Anthracimycin is produced from micro-organisms lurk in the ocean sediments that researchers discovered. Maybe because coming from marine sediments should anthracimycin chemical structure is very different from the composition of the existing antibiotics and this makes the bacteria more difficult in the drug resistance anthracimycin.

Panda

The researchers at the Nanjing Agricultural University, China discovered in Panda's blood contains a powerful antibiotic compounds called cathelicidin-AM help them against bacteria and fungi. This compound can kill bacteria in less than one hour. The experts are trying to research this component extract on drug treatment in humans.

Leaf-cutting ants in South America

Ants use simultaneously several kinds of antibiotics to eradicate the harmful fungi and bacteria do not desire in mushroom growing areas to make food for larvae and ants. TS. Matt Hutchings, a biologist at the University of East Anglia in England the same associates have conducted successfully separated bacteria symbiotic actinomycte on the body. This discovery opens up the prospect of an antibiotic treatment for bacterial disease caused by the fungus causing in humans.

Trilactol

Trilactol

Trilactol enzyme pills to cure digestive disorders, inflammatory bowel disease and chronic level, restored the balance of intestinal bacteria
 

Component

Each pack contains: mixed bacteria b. lactic acid (Lactobacillus acidophilus, Bifidobacterium longum, Lactobacilus rhamnosus) 300mg

Excipient just enough

Pharmacy resources

Mixture of probiotics re-balance the intestinal bacteria by system hold, occupy the intestines and nutrient competition with harmful bacteria.

Works in the case of lactose intolerance

Prevent constipation

Stimulates the immune system

Specify

-The case of diarrhea, intestinal inflammation and chronic supply

-Digestive disorders, constipation

-Restoring the balance of gut bacteria breaks down due to the use of antibiotics.

Dosage

-Diarrhea: 3-6 Pack/day

-Constipation: 3 Pack/day until stable

-Children use ½ adult dose

Contraindications

Hypersensitivity to the drug component.

2 in 1 effects: injection to cure diabetes obesity reduction effects

According to information from the Ministry of health of America said, Liraglutide, a drug injected treatment of diabetes is the Government permission to use the 2014 also helps obese people lose weight effectively.

A study lasting for a year was announced on 1/7 on New England medicine Journal said thanks to the drugs on the market is Saxenda name of Novo Nordisk, most patients have reduced scale resulted during the 56-week study.

Testing at 191 locations on the 27 countries at ages over 18

The experiment was conducted randomly in 191 locations in 27 countries in Europe, North America, South America, Asia, Africa and Oceania.

The subjects involved in research are 18 years or older and have a body mass index (BMI) of 30 or higher. A person is said to have a healthy body weight if BMI in the 19-25. Among the study participants 3731, about 2/3 were taking the drug Saxenda combined exercise to improve your living habits.

The remaining group also involved in tuning the routine life but was no placebo healing effects. Those taking the drug prescribed high doses than prescribed for the treatment of diabetes (3 mg) and also be injected under the skin (1.8 mg).

Results after research showed the number of weight reduction on average 3 kg/person

Following results of experiments showed that those in the placebo group, reducing the average about 3 kg. Meanwhile, the average drug users reduced 3 times that figure.

In total, 63% of those in the group taking liraglutide reduced by at least 5% of the body weight, much higher than the rate of 27% in the placebo group. However, liraglutide also has side effects including stomach pain, gallstones and an increased risk of breast cancer.

Known to have about 35% of adult Americans (about 100 million), are having to live with obesity. America ever introduce two drugs against obesity in 2012 are not widely used due to carry more side effects.

Arginin and uses on Cardiology

Arginin (in the form of L-arginin) is an amino acid involved in the process creates urea in the liver regulate the concentration of ammonia in the body should have the function of liver detoxification.

L-arginine, solutions for erectile disorder

In the specify before, arginin are typically used primarily in the treatment of liver dysfunction support such as:

-Chronic liver Inflammation.

-Fatty liver.

-Cirrhosis of the liver.

-Liver failure ...

Arginin-containing preparations are usually presented in the form of pills, water pills or infusion. Arginin (in the form of L-arginin) is an amino acid involved in the process creates urea in the liver regulate the concentration of ammonia in the body should have the function of liver detoxification.

Arginin (in the form of L-arginin) is an amino acid involved in the process creates urea in the liver regulate the concentration of ammonia in the body should have the function of liver detoxification.

L-arginine, solutions for erectile disorder

In the specify before, arginin are typically used primarily in the treatment of liver dysfunction support such as:

-Chronic liver Inflammation.

-Fatty liver.

-Cirrhosis of the liver.

-Liver failure ...

Arginin-containing preparations are usually presented in the form of pills, water pills or infusion.

Arginin supplies for very rich body because many of the foods such as red meat, poultry, fish, wheat, grains and dairy products.

In addition to taking on the functions of liver detoxification, arginin also has many other functions in the body:

-Wound healing.

-Help the kidneys remove waste from the body.

-Maintain endocrine and immune functions in the body.

-Bring the good works on Cardiology: prevention relax blood vessels and increase the circulation of blood in the circulatory system.

Arginin are used in the treatment of cardiovascular diseases support ...

The uses of Arginin on Cardiology

Currently, the good uses on cardiovascular arginin has increasingly been paying attention:

When inside the body, arginin is transformed into nitric oxide (NO), neurotransmitters vasodilatory effects, enhances the circulation of blood in the circulatory system. Thus arginin work do to lower blood pressure and improve blood circulation.

In addition, when there is sexual stimulation, nitric oxide will be released and stimulate the process of synthesis of GMP (guanosin monophosphat) the ring increases the blood flow to be hang in the penis. Therefore, arginin also cause penis erection.

So, in addition to using arginin in treating liver dysfunction support according to the specified previously, currently arginin are used in the treatment of cardiovascular diseases support such as: high blood pressure, angina, heart failure and erectile dysfunction.

Arginin also cause penis erection.

The note when using arginin

Arginin in treatment use the support above, need to be the physician, the patient cannot be arbitrarily used.

Arginin can cause side effects: abdominal pain, flatulence, diarrhea, increase the risk of gout ....

Avoid coordination arginin with drugs that lower blood pressure (losartan, captopril, amlodipine ...), the smoking group nitrates (nitroglycerin, dinitrat, isosorbid isosorbid mononitrat) and erectile dysfunction treatment drugs (sildenafil citrate, tadalafil, vardenafil) for causing the drug interactions.Arginin (in the form of L-arginin) is an amino acid involved in the process creates urea in the liver regulate the concentration of ammonia in the body should have the function of liver detoxification.

Arginin (in the form of L-arginin) is an amino acid involved in the process creates urea in the liver regulate the concentration of ammonia in the body should have the function of liver detoxification.

L-arginine, solutions for erectile disorder

In the specify before, arginin are typically used primarily in the treatment of liver dysfunction support such as:

-Chronic liver Inflammation.

-Fatty liver.

-Cirrhosis of the liver.

-Liver failure ...

Arginin-containing preparations are usually presented in the form of pills, water pills or infusion. Arginin (in the form of L-arginin) is an amino acid involved in the process creates urea in the liver regulate the concentration of ammonia in the body should have the function of liver detoxification.

Arginin (in the form of L-arginin) is an amino acid involved in the process creates urea in the liver regulate the concentration of ammonia in the body should have the function of liver detoxification.

L-arginine, solutions for erectile disorder

In the specify before, arginin are typically used primarily in the treatment of liver dysfunction support such as:

-Chronic liver Inflammation.

-Fatty liver.

-Cirrhosis of the liver.

-Liver failure ...

Arginin-containing preparations are usually presented in the form of pills, water pills or infusion.

Arginin supplies for very rich body because many of the foods such as red meat, poultry, fish, wheat, grains and dairy products.

In addition to taking on the functions of liver detoxification, arginin also has many other functions in the body:

-Wound healing.

-Help the kidneys remove waste from the body.

-Maintain endocrine and immune functions in the body.

-Bring the good works on Cardiology: prevention relax blood vessels and increase the circulation of blood in the circulatory system.

Arginin are used in the treatment of cardiovascular diseases support ...

The uses of Arginin on Cardiology

Currently, the good uses on cardiovascular arginin has increasingly been paying attention:

When inside the body, arginin is transformed into nitric oxide (NO), neurotransmitters vasodilatory effects, enhances the circulation of blood in the circulatory system. Thus arginin work do to lower blood pressure and improve blood circulation.

In addition, when there is sexual stimulation, nitric oxide will be released and stimulate the process of synthesis of GMP (guanosin monophosphat) the ring increases the blood flow to be hang in the penis. Therefore, arginin also cause penis erection.

So, in addition to using arginin in treating liver dysfunction support according to the specified previously, currently arginin are used in the treatment of cardiovascular diseases support such as: high blood pressure, angina, heart failure and erectile dysfunction.

Arginin also cause penis erection.

The note when using arginin

Arginin in treatment use the support above, need to be the physician, the patient cannot be arbitrarily used.

Arginin can cause side effects: abdominal pain, flatulence, diarrhea, increase the risk of gout ....

Avoid coordination arginin with drugs that lower blood pressure (losartan, captopril, amlodipine ...), the smoking group nitrates (nitroglycerin, dinitrat, isosorbid isosorbid mononitrat) and erectile dysfunction treatment drugs (sildenafil citrate, tadalafil, vardenafil) for causing the drug interactions.

The first pharmaceutical use 3D printing technology

Spritam name pharmaceutical drug is in the form of capsules used to treat seizures epilepsy patients was first U.s. license for using 3D printing technology.

Spritam name pharmaceutical drug is in the form of capsules used to treat seizures epilepsy patients was first U.s. license for using 3D printing technology.

Aprecia pharmaceuticals company based in the State of Ohio said in the airline's system allows the production of the tablet with up to 1000 mg/capsules.

Through the 3D printing process, the tablet was created as a porous, can melt easily in a small amount of fluid, causing the use of medication more convenient for children as well as the dysphagia.

3D printing technology was invented in the 80s of the last century, the use of a laser to create the physical metal or plastic according to digital design. The point of this technology is creating templates and customize the device quickly with low cost.

Does the medical industry are pushing the application of advanced technology to manufacture the parts of complex implant for patients with rare disease or meet special injury.

Speaking to the press, FDA spokesman Sandy Walsh said Spritam is the first drug produced by 3D printing technology is the Agency on through. Spritam, also called Levetiracetam, were circulating on the market for many years in many different formats.

Previously, the FDA has also "green light" for a number of other medical products manufactured by 3D printing as the artificial parts replaced in the human body.

Under the plan, Aprecia will begin distributing the drugs on the in the 1st quarter of next year. The company also said in the future will continue to use this advanced technology to develop many other drugs.

In recent years, the 3D printing technology is increasingly developing strong and companies were able to use them to create complex objects from metals, such as titanium or aluminium.

Aspirin can reduce the risk of cancer in people who are overweight

A randomized trial in the uk showed that cancer risk often increases in overweight people can will reverse when regular doses of aspirin daily.

The research was published in the Journal of Clinical Oncology, is funded by the Uk Medical Research Council, cancer research Uk.

Randomized trials have shown that the risk of cancer often increase in overweight people can will reverse when regular doses of aspirin.

Aspirin is a type of non-steroidal anti-inflammatory drug (NSAID) that can be used for pain relief, antipyretic and anti-inflammatory.

The researchers evaluated the effectiveness of drugs in a 10-year-long research on 937 Lynch syndrome-a genetic disorder diseases that increase the risk of cancer, especially cancer of the colon and uterine cancer.

Among these patients, the researchers found that being overweight will double the risk of colon cancer. However, this risk can be reversed with the use of regular doses of aspirin

"This is very important for the people with Lynch syndrome," study author Sir John Burn, Professor of Clinical Genetics at Newcastle University in England said. "A lot of people struggle with cancer risks due to excess weight and this shows that cancer risk can be eliminated by using an aspirin."

In this study, a group of researchers from more than 43 in 16 countries have provided a test to improve the participant's Lynch Syndrome was assigned at random into two groups: half are taking two aspirin (600 mg) per day for 2 years and the other half placebo.

The participants are then monitored for 10 years, at which a total of 55 people developed colon cancer. The researchers discovered that those involved in obesity is likely to develop into cancer folded 2.75 times the participants had normal weight.

However, among the participants drank 2 aspirin each day, the researchers found that the risk of cancer of the colon is the same whether the participants have been obese or not.

Per unit of body mass index (BMI) increased to increase the risk of colon cancer is 7%. John Mathers, Professor of human nutrition at the University of Newcastle, said that surprisingly the obesity is a driver of cancer even in those with a genetic predisposition to this disease.

"Indeed, the risk of obesity related has increased twice the risk for people with Lynch syndrome as well as for the general population," he added.

Because aspirin appears to stop before the earliest stages of the tumor when it develops, the researchers believe that aspirin can affect the ease of cells becoming cancerous.

Quick information about aspirin

Aspirin is often used as a form of mild pain, reducing fever and anti-inflammatory.

Aspirin is also indicated to prevent blood clot formation in patients at high risk of having a heart attack and stroke

Worldwide estimates there are about 40000 tons of aspirin are consumed annually.

"We can see a mechanism in humans, according to which aspirin is recommended genetic damage from stem cells to undergo cell death," Professor Burn shows. " This will have an impact on cancer. "

One possibility is that aspirin inhibits inflammatory response or increase in obesity. There is increasing evidence that when the process of inflammation associated with an increased risk of cancer.

While everyone should try to maintain a balance weight, PROF. Mathers suggests that aspirin may help patients suffering from obesity are difficult to find a way to lose weight.

The researchers believe that the need to conduct further studies to confirm and identify the correct level of protection aspirin for people have a high BMI.

GS Burn also said that anyone before you start taking aspirin regularly, they need to consult a physician, because aspirin can cause some side effects for the stomach, such as inflammation, ulcers. He adds:

"But if there is a family history of high cancer risk, weigh between benefits and costs, especially side effects with the stomach, we can use the aspirin"

The researchers now plan to conduct a larger track trials related to 3000 participants from around the world to examine the influence of different doses of aspirin and reviewed with a lower dose may be sufficient to protect the body.